Cisplatin, rather than oxaliplatin, increases paracellular permeability of LLC-PK1 cells via activating protein kinase C
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چکیده
منابع مشابه
Overexpression of claudin-7 decreases the paracellular Cl- conductance and increases the paracellular Na+ conductance in LLC-PK1 cells.
Tight junctions form the primary barrier regulating the diffusion of fluid, electrolytes and macromolecules through the paracellular pathway. Claudins are the major structural and functional components of tight junction strands and are considered as the best candidates for forming paracellular channels. They are a family of integral membrane proteins with more than 20 members and show distinct ...
متن کاملRegulation by forskolin of cyclic AMP phosphodiesterase and protein kinase C activity in LLC-PK1 cells.
Forskolin, a naturally occurring activator of adenylate cyclase, inhibits total and high-affinity cyclic AMP phosphodiesterase activity in soluble and particulate fractions of cultured LLC-PK1 renal epithelial cells. The naturally occurring forskolin analogue 1,9-dideoxyforskolin, which does not stimulate adenylate cyclase activity, is a more potent inhibitor of cyclic AMP phosphodiesterase act...
متن کاملCisplatin-induced renal injury in LLC-PK1 cells
Nephrotoxicity is one of the important adverse effects induced by cisplatin (CDDP), a potent anticancer drug. CDDP causes a disorder of renal proximal tubules. So, we evaluated mechanisms of renal tubular injury induced by CDDP using established epithelial cell line, LLC-PK1, which is characteristic of renal proximal tubular epithelium. LLC-PK1 cells were incubated in culture media except CDDP ...
متن کاملCalcitonin-induced increase in phosphate accumulation in LLC-PK1 cells probably through protein kinase C activation.
To assess the role of protein kinase C and cAMP on the calcitonin-induced alteration of phosphate accumulation by renal tubular cells, the effects of phorbol esters, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), and DBcAMP on the phosphate accumulation in LLC-PK1 cells were investigated. Calcitonin stimulated phosphate accumulation with a concomitant increase in cAMP production. Phorbol ...
متن کاملSodium butyrate increases glucose transporter expression in LLC-PK1 cells.
The effect of sodium butyrate on the expression of the facilitated glucose transporter (GT) was investigated in the pig kidney cell line LLC-PK1. When cells were treated with butyrate, GT mRNA expression was remarkably enhanced with a maximal effect at 5 mM. Levels of GT mRNA were increased at 1 day after butyrate treatment and continued to increase for at least 4 days; however, acetate and pro...
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 2020
ISSN: 1347-4367
DOI: 10.1016/j.dmpk.2019.09.001